Discovery of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist.

Bioorganic & Medicinal Chemistry Letters（2012）

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摘要

A description of the discovery process of CS-2100, a potent, orally active, S1P3-sparing S1P1 agonist has been provided. Its 4-ethyl thiophene structure contributes S1P3-sparing property significantly, which is in accordance with the result of our docking studies with homology models.

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关键词

S1P1,Agonist,CS-2100,Lymphocyte,HvGR

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