Synthesis and antikinetoplastid activity of a series of N,N'-substituted diamines.
Bioorganic & Medicinal Chemistry Letters（2012）
Abstract
A series of N,N′-substituted diamines were prepared. The most potent compounds have 50% parasite growth inhibition at submicromolar (against Trypanosoma cruzi) or nanomolar (against Trypanosoma brucei and Leishmania donovani) range.
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Key words
Leishmaniasis,Chagas’ disease,Human African trypanosomiasis,Diamines,Reductive amination
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