Role of microsomal ethanol-oxidizing system in regulation of linoleoyl-CoA desaturase activity after long-term ethanol administration.
ALCOHOL AND ALCOHOLISM(1988)
Abstract
Chronic ethanol administration resulted in a decrease of rat liver linoleoyl-CoA desaturase activity and an activation of MEOS. This was accompanied by an increase in the activity of the NADPH-dependent system and the oxidation rate of NADH-oxidase, which suggests transfer of electrons from NADH to cytochrome P-450. The decreased linoleoyl-CoA desaturase activity may be due to insufficient supply of electrons, because of possible diversion to MEOS.
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Key words
ethanol-oxidizing,linoleoyl-coa,long-term
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