Small intestinal malabsorption in chronic alcoholism: a retrospective study of alcoholic patients by the ¹⁴C-D-xylose breath test.

Objective. The C-14-D-xylose breath test was used at Ulleval University Hospital in the period from 1986 TO 1995 for malabsorption testing. The objective of this retrospective study was to reveal whether patients with chronic alcoholism may have intestinal malabsorption. Materials and methods. The consecutive C-14-D-xylose breath test database was reviewed and patients with the diagnosis of chronic alcoholism were identified. C-14-D-xylose breath test results of the alcoholic patients were compared with the results of untreated celiac patients and patient and healthy controls. In the C-14-D-xylose breath test, C-14-D-xylose was dissolved in water and given orally after overnight fast. Breath samples were taken at 30-min intervals for 210 min, and (CO2)-C-14 : (CO2)-C-12 ratios were calculated for each time point, presenting a time curve for C-14-D-xylose absorption. Urine was collected after 210 min and the fraction of the total D-xylose passed was calculated (U%). (CO2)-C-14 in breath and C-14-D-xylose in urine were analyzed using liquid scintillation. Results. Both breath and urine analysis revealed a pattern of malabsorption in alcoholics comparable with untreated celiac patients, with significantly reduced absorption of D-xylose compared with patient and healthy controls. Conclusion. Alcoholic patients have a significantly reduced C-14-D-xylose absorption, comparable with untreated celiac patients. This indicates a reduced intestinal function in chronic alcoholism.