Antimicrobial activity of new phorbins from Jatropha curcas Linn. (Euphorbiaceae) leaves.
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES(2011)
Abstract
The crude methanol extract of Jatropha curcas leaves exhibited activity against Staphylococcus aureus, Bacillus subtilis, Mycobacterium phlei, Candida albicans, and Trichophyton mentagrophytes but was inactive against Escherichia coli, Pseudomonas aeruginosa, and Saccharomyces cerevisiae. In a bioassay-directed fractionation, two new phorbins were isolated and analysed by spectroscopic methods. Isolate 1 was characterized as an analogue of pheophytin b with a phytyl moiety containing three double bonds which are at positions P2/P3, P6/P7, and P10/P11. Compound 2 was characterized as methyl pheophorbide a with 13(2)-OH and 17- and 17(1)-CH3 moieties. It is active against Serratia marcescens.
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Key words
Pheophytin b Analogue,Methyl Pheophorbide a Analogue,Serratia marcescens
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