Microxine, a new cdc2 kinase inhibitor from the Australian marine sponge Microxina species.

A new purine derivative microxine (1) was isolated from the Australian marine sponge Microxina sp. The compound was isolated via reversed-phase chromatography and its structure determined spectroscopically. Microxine was found to weakly inhibit cdc2 kinase activity with an IC50 of 13 muM.