Recurrent pericardial effusion associated with hypothyroidism in Down Syndrome: a case report.
West African journal of medicine(2011)
摘要
BACKGROUND:The complex of Down Syndrome-hypothyroidism-pericardial effusion is largely unreported in sub-Sahara.
OBJECTIVE:To present and highlight an unusual manifestation of hypothyroidism.
METHODS:A 16-year-old girl with confirmed Down Syndrome presented with complaints of generalised body swelling of eight months' duration. Her work-up consisted of full clinical and laboratory evaluation including ECG and echocardiography.
RESULTS:The patient was diagnosed of Down's Syndrome at birth but was lost to follow-up after at eight years of age. Body swelling was associated with clinical features of heart failure. Echocardiography showed massive pericardial effusion. Serum l-thyroxine was less than 0.5mg/dl and TSH >40iu/l. The heart failure and menstrual irregularities responded to l-thyroxine therapy.
CONCLUSION:This appears to be the first report of the complex of Down syndrome, hypothyroidism and pericardial effusion in a Nigerian child. Thyroid function test is therefore recommended as a part of baseline investigation for Nigerian children with Down syndrome as is the practice.
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关键词
Ehlers-Danlos Syndrome
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