The isolation of a metastable conglomerate using a combined computational and controlled crystallization approach.
CHEMICAL COMMUNICATIONS(2012)
Abstract
While the use of additives to control the crystallization of polymorphs is well known, similar methodology to promote the crystallization of a metastable conglomerate over a stable racemic compound in enantiomeric systems has not been reported. Here we demonstrate this phenomenon in the case of 2-chloromandelic acid.
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Key words
Crystallization,Ultrasound-Assisted Crystallization,Continuous Crystallization,Pharmaceutical Crystallization
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