Discrimination between T/A and A/T base pairs of pyrrole-imidazole polyamides substituted with chiral β-hydroxy-γ-aminobutyric acid/β-alanine pairs.

Base-T-specific recognition element: A chiral aliphatic amino acid, (S)-β-hydroxyl-γ-aminobutyric acid, when incorporated into polyamides, can act as a novel T-specific recognition element in DNA minor groove sequence-specific recognition event. Good flexibility of the novel T-reader implies that it could be incorporated into longer polyamides to regulate their curvature and thus allow discrimination of longer DNA sequences. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.