Hyperalgesic activity of kisspeptin in mice

Simona Spampinato,Angela Trabucco,Antonella Biasiotta,Francesca Biagioni,Giorgio Cruccu,Agata Copani,William H Colledge,Maria Angela Sortino,Ferdinando Nicoletti,Santina Chiechio

Molecular Pain（2011）

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摘要

Kisspeptin is a neuropeptide known for its role in the hypothalamic regulation of the reproductive axis. Following the recent description of kisspeptin and its 7-TM receptor, GPR54, in the dorsal root ganglia and dorsal horns of the spinal cord, we examined the role of kisspeptin in the regulation of pain sensitivity in mice.

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关键词

Kisspeptin,GPR54,inflammatory pain,nociceptive sensitization

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