The discovery of AZD9164, a novel muscarinic M3 antagonist.

Antonio Mete,Keith Bowers,Eric Chevalier,David K Donald,Helen Edwards,Katherine J Escott,Rhonan Ford,Ken Grime,Ian Millichip,Barry Teobald,Vince Russell

Bioorganic & Medicinal Chemistry Letters（2011）

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摘要

The optimization of a new series of muscarinic M3 antagonists is described, leading to the identification of AZD9164, which was progressed into the clinic for evaluation of its potential as a treatment for COPD.

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关键词

COPD,Muscarinic M3 antagonist,Bronchoconstriction,Salivation,Selectivity

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