Combining two-directional synthesis and tandem reactions: a short formal synthesis of halichlorine.

Camille Gignoux,Annabella F Newton,Alexandre Barthelme,William Lewis,Marie-Lyne Alcaraz,Robert A Stockman

ORGANIC & BIOMOLECULAR CHEMISTRY（2012）

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摘要

A short and efficient synthesis of an advanced intermediate (1) in the Clive route to halichlorine has been achieved in 12 steps and 13.2% yield by a combined two-directional synthesis/tandem reaction strategy.

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