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BENADROSTIN, NEW INHIBITOR OF POLY(ADP-RIBOSE) SYNTHETASE, PRODUCED BY ACTINOMYCETES .2. STRUCTURE DETERMINATION

S YOSHIDA,H NAGANAWA,T AOYAGI,T TAKEUCHI,H UMEZAWA

The Journal of antibiotics（1988）

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Abstract
Benadrostin, a new inhibitor of poly(ADP-ribose) synthetase, has been isolated from the culture broth of Streptomyces flavovirens MH499-O'F1. The structure of benadrostin was defined as 8-hydroxy-2H-1,3-benzoxazine-2,4-dione by an analysis of spectral properties and chemical studies of benadrostin and its derivatives.
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Key words
actinomycetes,new inhibitor,synthetase,adp-ribose
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