Methodological aspects of bone marrow research using 111In-citrin]

A study of 111In-citrin distribution and kinetics in the body of patients without hemopoietic disorder showed the accumulation (up to 20%) of the injected drug in the bone marrow. Organ fixation, elimination and other pharmacokinetic indices confirming 111In-citrin functional applicability for investigation of the red bone marrow were determined shortly after intravenous injection and in 24 h using a total body meter. These data formed the basis for the calculation of radiation exposures and the solution of methodological problems related to a radionuclide study of the bone marrow in cancer and leukemic patients. 111In concentration in the pelvic bones determined with the help of the total body meter, reflected the total red bone marrow functional activity and was in reverse correlation with a RP elimination value. Total body scintigraphy 24 h after the drug administration made it possible to visualize the bone marrow distribution in the body and to reveal signs of general or local disorders of bone marrow functional activity in leukemias or malignant tumors after combination therapy.