Solid pseudopapillary tumors of the pancreas: a case series, comparison of histopathological and clinical data.

Solid pseudopapillary neoplasms (SPNs) are rare pancreatic tumors. They occur most frequently in young females and are often diagnosed accidentally. SPNs are characterized by an excellent clinical outcome. In our case series the clinical course, pathohistological data and clinical outcome of eight patients (7 female patients, 1 male patient) with SPN are described. Histological examination as well as immunohistochemical analysis shows similar results in all eight cases. Although in the literature a few cases of SPNs with bad prognosis have been reported, up to now none of our patients shows any signs of recurrence or metastasis. Moreover, we give in this case series a summary of SPNs in the literature, important clinical and pathological differential diagnosis, and additionally discuss relevant differential diagnosis occurring in daily routine work.