Successful Treatment Of Necrotizing Fasciitis In An Upper Extremity Caused By Clostridium Perfringens After Bone Marrow Transplantation
INTERNAL MEDICINE(2011)
Abstract
We report a 47-year-old man with acute leukemia who survived a severe case of necrotizing fasciitis caused by Clostridium perfringens involving his right upper extremity. On day 5 after stem cell transplantation, progressive local tissue necrosis led to septicemia and disseminated intravascular coagulation. Early diagnosis and prompt initiation of appropriate therapy, including surgical debridement and broad-spectrum antibiotics, were crucial. A recombinant thrombomodulin might have not only resolved the coagulation problem but also prevented multiple organ failure associated with the systemic inflammatory response.
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Key words
necrotizing fasciitis, Clostridium perfringens, disseminated intravascular coagulation, recombinant thrombomodulin
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