Design, structure-activity relationship, and highly efficient asymmetric synthesis of 3-phenyl-4-benzylaminopiperidine derivatives as novel neurokinin-1 receptor antagonists.
Bioorganic & Medicinal Chemistry（2011）
Abstract
A series of novel and potent 3-phenyl-4-benzylaminopiperidine tachykinin NK1 antagonists are described. Highly efficient asymmetric synthesis of this series is achieved via dynamic kinetic resolution.
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Key words
Tachykinin,NK1 receptor,3-Phenyl-4-benzylaminopiperidine,Asymmetric synthesis,Dynamic kinetic resolution
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