AFM imaging of RGD presenting synthetic extracellular matrix using gold nanoparticles.
MACROMOLECULAR BIOSCIENCE(2008)
摘要
Several high-resolution imaging techniques such as FESEM, TEM and AFM are compared with respect to their application on alginate hydrogels, a widely used polysaccharide biomaterial. A new AFM method applicable to RGD peptides covalently conjugated to alginate hydrogels is described. High-resolution images of RGD adhesion ligand distribution were obtained by labeling biotinylated RGD peptides with streptavidin-labeled gold nanoparticles. This method may broadly provide a useful tool for sECM characterization and design for tissue regeneration strategies.
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关键词
atomic force microscopy (AFM),biomaterials,electron microscopy,hydrogels,TEM
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