Sulfonamides as selective oestrogen receptor β agonists.
Bioorganic & Medicinal Chemistry Letters(2011)
摘要
A series of p-hydroxybenzenesulphonamides ERβ receptor agonists were discovered and several compounds identified had excellent selectivity over the related ERα receptor. One of these, compound 11, had an interesting binding conformation determined by X-ray and represents an excellent starting point in the quest for further selective ERβ agonists.
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关键词
ERβ agonist,Oestrogen receptor,Nuclear hormone receptor,Sulfonamides
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