High HPA-axis activation disrupts the link between liking and wanting with liking and wanting related brain signaling
Physiology & Behavior(2012)
Abstract
Background
Eating behavior changes under stress, i.e. during high HPA-axis activation.
Aim
Assessment of effects of high versus low HPA-axis activation on liking and wanting related brain signaling in relevant regions.
Methods
15 female subjects (21.5±0.4years, BMI=22.2±0.4) completed fMRI scans on 2days, in a fasted as well as a satiated condition on each day. The days were sorted by HPA-axis activation, resulting in two sufficiently separated HPA-axis states which were statistically confirmed (p<.05). During scans, subjects rated liking and wanting for food images; wanting indicated food choice for the subsequent meal. Energy-intake, hunger and fullness were additionally recorded.
Results
Hunger changed significantly over the meal (p<.001). Energy intake was lower during the second meal (p<.001). Behavioral wanting was lower after breakfast (p<.01), behavioral liking did not change. During low HPA-activation, liking task related signaling (TRS) pre-meal in the anterior insula predicted behavioral liking, wanting TRS in the anterior insula, nucleus accumbens and thalamus predicted behavioral wanting. During high HPA-activation, these relationships were not present pre-meal, but post-meal behavioral liking was predicted in the nucleus accumbens and wanting in the caudate.
Conclusion
High HPA-axis activation disrupted and redirected the connection of behavioral liking/wanting with the specifically associated brain signaling in relevant regions.
MoreTranslated text
Key words
HPA-axis,Cortisol,Reward,Liking and wanting,Food choice,fMRI
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined