Regulation Of Cd69 Expression On Eosinophil Precursors By Interferon-Gamma
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY(2000)
摘要
The purpose of this study was to determine whether interferon-gamma (IFN-gamma) induced CD69 expression by eosinophil precursors, Eosinophil precursors were induced from CD34+ cord blood cells using recombinant human interleukin-3 (IL-3) and interleukin-5 (IL-5), On day 14 of culture, cells constitutively expressed CD69 and the IFN-gamma receptor (IFN-gamma R), Stimulation with IFN-gamma for 24 h did not affect IFN-gamma R expression by the cells, On the other hand, IFN-gamma significantly upregulated CD69 expression by the precursors after 24 h of incubation. A specific JAK2 inhibitor (AG-490) caused a concentration-dependent suppression of IFN-gamma-induced CD69 expression by the precursors. In conclusion, these results indicate that IFN-gamma induces CD69 expression by eosinophil precursors via the activation of JAK2, Copyright (C) 2000 S. Karger AG, Basel.
更多查看译文
关键词
eosinophils, interferon-gamma, interferon-gamma receptor, JAK2, CD69
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要