Salmonella Enterica Serovars Typhimurium And Dublin Can Lyse Macrophages By A Mechanism Distinct From Apoptosis

PATRICIA R. WATSON,ANNE V. GAUTIER,SUE M. PAULIN,A. PATRICIA BLAND,PHILIP W. JONES,TIMOTHY S. WALLIS

INFECTION AND IMMUNITY（2000）

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摘要

Salmonella enterica serovars Typhimurium and Dublin lysed primary bovine alveolar macrophages and immortalized J774.2 macrophage-like cells in the absence of either the morphological changes or DNA fragmentation characteristic of apoptosis. Macrophage lysis mas dependent on a subset of caspases and an intact sipB gene.

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关键词

apoptosis,caspases,cell death,membrane proteins,lysis,serovars

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