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Analysis Of Monomeric Mutants Of Hsc70: A Possible Relationship Between Oligomerization And Functional Properties

Mouna Amor-Mahjoub,Nathalie Gomez-Vrielyunck,Jean Philippe Suppini,Benoit Fouchaq,Nadia Benaroudj,Moncef Ladjimi

PROTEIN AND PEPTIDE LETTERS（2007）

Cited 25|Views9
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Abstract
Data of this study showed that alpha D-alpha E helices and the conserved interdomain linker are two interfaces essential not only for the self-association but also for the functional properties of rat HSC70. Self-association which is a conserved property of HSP70 seems to be important for the activity of these proteins.
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Key words
HSC70,mutagenesis,oligomerization,ultracentrifugation,ATPase activity
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