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A study on the pharmacokinetics in mouse of adenine-9- β -D-arabinofuranoside-5-monophosphate conjugated with lactosaminated albumin

L. Fiume,B. Bassi,C. Busi,A. Mattioli,Th. Wieland

Experientia（1985）

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Abstract
Summary In plasma of mice injected with adenine-9-β-D-arabinofuranoside monophosphate (ara-AMP) coupled to human lactosaminated serum albumin (L-HSA) some of the ara-AMP molecules are enzymatically released, whereas others remain linked to L-HSA. Evidence has been obtained that ara-AMP is not deaminated when it is conjugated to L-HSA, in contrast to the free drug which is rapidly metabolized to its hypoxanthine derivative.
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Key words
serum albumin,drug targeting
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