Cholesterol oxidation products and their biological importance

Waldemar Kulig,Lukasz Cwiklik,Piotr Jurkiewicz,Tomasz Rog,Ilpo Vattulainen

Chemistry and Physics of Lipids（2016）

Cited 133|Views4

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Abstract

•Oxidation of cholesterol leads to quite dramatic changes in cell membrane properties.•Oxysterols are formed in vivo in both enzymatic and nonenzymatic ways.•Oxysterols play a crucial role in numerous biological processes.

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chol,7α/β-OOH-chol,7α/β-OH-chol,7-Keto-chol,24S-OH-chol,27-OH-chol,4β-OH-chol,25-OH-chol,5-COOH-chol,24S,25-Epoxy-chol,27-OH-7-Keto-chol,3β-OH-COOH-chol,7-Keto-chol-3-sulf,5α/β,6α/β-Epoxy-chol,26-OH-chol,22-OH-chol,20α/β-OH-chol,19-OH-chol,4β-OH-chol,5-OH-chol,3α/β,5α/β,6α/β-3OH-chol,3β-OH-chol,22-Keto-chol,cholestenone,7α,25-2OH-chol,CH25H,ER,ROS,HDL,LDL,LXR,SREBPs,Insig,EBI2,BBB,DPH,TDFS,POPC,DRM,AD,Aβ,PD,HD,MS,AMD,RPE

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