N-(5-chloro-2-(hydroxymethyl)-N-alkyl-arylsulfonamides as gamma-secretase inhibitors.

Michael F Parker,Donna M Barten,Carl P Bergstrom,Joanne J Bronson,Jason A Corsa, Milind S Deshpande,Kevin M Felsenstein,Valerie L Guss, Steven B Hansel,Graham Johnson, Daniel J Keavy, Wai Y Lau, Jeremy Mock, C V C Prasad,Craig T Polson, Charles P Sloan,David W Smith,Owen B Wallace,Henry H Wang,Andrew Williams,Ming Zheng

Bioorganic & medicinal chemistry letters（2007）

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摘要

A series of N-alkylbenzenesulfonamides were developed from a high throughput screening hit. Classic and parallel synthesis strategies were employed to produce compounds with good in vitro and in vivo gamma-secretase activity.

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