Cerebrospinal fluid IgM index correlates with cranial MRI lesion load in patients with multiple sclerosis.
EUROPEAN NEUROLOGY(2007)
Abstract
In multiple sclerosis intrathecal IgM synthesis correlates with an unfavourable disease course. Whether this reflects a pathogenic role of IgM, possibly in conjunction with complement, is a matter of debate. In a cross-sectional study we measured intrathecal synthesis of IgM and the complement component C3, and on cranial MRI lesion load and central brain atrophy in clinically active patients, 17 relapsing-remitting, 16 secondary progressive. Correlative analysis showed that in relapsing-remitting patients CSF IgM index correlated with cranial MRI T-2 and T-1 lesion load, and central brain atrophy; and the C3 index correlated with T-2 lesion load. In secondary progressive patients CSF IgM index correlated with periventricular T-2 lesion load. Our data are in favour of a pathogenic role of IgM in multiple sclerosis. Copyright (C) 2007 S. Karger AG, Basel
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Key words
multiple sclerosis,cerebrospinal fluid,IgM,intrathecal synthesis,cranial MRI
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