Personalized medicine for mucositis: Bayesian networks identify unique gene clusters which predict the response to gamma-d-glutamyl-l-tryptophan (SCV-07) for the attenuation of chemoradiation-induced oral mucositis

Gamma-d-glutamyl-l-tryptophan (SCV-07) demonstrated an overall efficacy signal in ameliorating oral mucositis (OM) in a clinical trial of head and neck cancer patients. However, not all SCV-07-treated subjects responded positively. Here we determined if specific gene clusters could discriminate between subjects who responded to SCV-07 and those who did not.