Fish Oil Feeding Up-Regulates The Expression Of 5-Aminolevulinate Synthase 2 Mrna In Rat Brain

Tomoaki Haraguchi,Noriyuki Yanaka,Yuko Eguchi,Takahiro Kudo,Atsuko Hirata,Norihisa Kato

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY（2011）

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摘要

In this study, we investigated the effect of fish oil on gene expression in the cerebral cortex, and found that 5-aminolevulinate synthase 2 (ALAS2) mRNA expression was up-regulated by fish oil feeding. ALAS2 promoter activity was found to be regulated by retinoic acid. Our results suggest that fish oil modulates neuronal functions via heme synthesis.

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5-aminolevulinate synthase, fish oil, docosahexaenoic acid

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