Hemodynamic And Metabolic Effects Of Ketanserin In Dyslipidaemic Hypertensive Subjects

Eighteen dyslipidaemic patients affected with moderate hypertension were studied before and after short-term treatment with ketanserin (40 mg/die) on hypocaloric (22-25 kcal/kg/die) and normosodic-normopotassic diet. Student's t test applied to the determinations revealed a significant reduction of systolic and diastolic blood pressure (SBP, p < 0.001, DBP p < 0.001), total cholesterol (p < 0.001) and triglycerides (p < 0.006). The results suggest that ketanserin is an effective hypotensive drug and its association with a hypocaloric diet promotes a decrease in plasma lipids.