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A CaMKIIβ signaling pathway at the centrosome regulates dendrite patterning in the brain

Sidharth V Puram,Albert H Kim,Yoshiho Ikeuchi,Joshua T Wilson-Grady,Andreas Merdes,Steven P Gygi,Azad Bonni

NATURE NEUROSCIENCE（2011）

Cited 76|Views19
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Abstract
This study reports that CaMKIIβ is recruited to the centrosome by PCM1, where it promotes dendrite retraction and pruning via the phosphorylation and inhibition of Cdc20-APC. This effect is independent of its association with CaMKIIα.
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Key words
Cell signalling,Neural patterning,Spine regulation and structure,Biomedicine,general,Neurosciences,Behavioral Sciences,Biological Techniques,Neurobiology,Animal Genetics and Genomics
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