Radiation effects on uptake of 99Tcm-hexamethylpropylen amine oxime (HMPAO) in head and neck tumours.
British journal of cancer(1991)
摘要
Twenty patients with malignant head and neck tumours were imaged with 99Tcm-labelled hexamethylpropylene amine oxime (HMPAO), a radiopharmaceutical generally used for blood flow studies. Before radiotherapy (RT), 93% of the tumours could be detected with single photon emission computed tomography (SPECT) and 45% with planar imaging. Whole tumour-to-background 99TcmHMPAO uptake ratios ranged from 3.6 to 1.0 (mean 1.7 +/- 0.6) in untreated tumours. There was a good correlation between tumour volume and uptake (r = 0.69, P = 0.002). Sixteen patients were reimaged during or shortly after radical RT. 99TcmHMPAO uptake was significantly lower after treatment (mean uptake ratio 1.2 +/- 0.3, P less than 0.001). However, RT associated changes in 99TcmHMPAO uptake were in agreement with the clinical response in only 63% of the studies. This study indicates that 99TcmHMPAO SPECT imaging can be used for pretherapeutic localisation of head and neck tumours. Although most tumours show a decrease in uptake after irradiation the poor association with tumour regression does not allow for reliable assessment of treatment response.
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nature, nature publishing group, BJC, British Journal Cancer, cancer research, cancers, prescription drugs, breast cancer, medical research laboratory, lung cancer, nature, prostate cancer, skin cancer, leukaemia, colon cancer, ovarian cancers, cervical cancer, liver cancer, cancer treatments, brain cancer, gene therapy, bone marrow, apoptosis, nature magazines, bone marrow transplant, science news articles, cell division, cancer cells, nature journals, oncogene, neoplasia, antioxidants, adipose tissue, science and nature, oncogene journals, tumours, cancer gene therapy, apoptosis pathway, anti cancer drugs, science research papers, anticancer
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