Improved signal processing to detect cancer by ultrasonic molecular imaging of targeted nanoparticles.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA(2011)
摘要
In several investigations of molecular imaging of angiogenic neovasculature using a targeted contrast agent, Renyi entropy [I(f)(r)] and a limiting form of Renyi entropy (I(f,infinity)) exhibited significantly more sensitivity to subtle changes in scattering architecture than energy-based methods. Many of these studies required the fitting of a cubic spline to backscattered waveforms prior to calculation of entropy [either I(f)(r) or I(f,infinity)]. In this study, it is shown that the robustness of I(f,infinity) may be improved by using a smoothing spline. Results are presented showing the impact of different smoothing parameters. In addition, if smoothing is preceded by low-pass filtering of the waveforms, further improvements may be obtained. (C) 2011 Acoustical Society of America. [DOI: 10.1121/1.3578459]
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