Inhibitor of DNA binding 2 promotes sensory axonal growth after SCI.

Panpan Yu,Yi-Ping Zhang,Lisa B E Shields,Yiyan Zheng,Xiaoling Hu,Rachel Hill,Russell Howard,Zhen Gu,Darlene A Burke,Scott R Whittemore,Xiao-Ming Xu,Christopher B Shields

Experimental Neurology（2011）

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摘要

This study investigated whether neuronal inhibitor of DNA binding 2 (Id2), a regulator of basic helix-loop-helix (bHLH) transcription factors, can activate the intrinsic neuritogenetic mode of dorsal root ganglion (DRG) neurons in adult mice following spinal cord injury (SCI).

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关键词

Id2,Gene delivery,DRG neuron,Axonal regeneration,Spinal cord injury

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