Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and typhoid susceptibility in Asian Malay population in Malaysia.

Saatheeyavaane Bhuvanendran,Hani M Hussin,Lila P Meran,Amy A Anthony,Leilei Zhang,Lauranell H Burch,Kia K Phua,Asma Ismail,Prabha Balaram

Microbes and Infection（2011）

Cited 12|Views6

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Abstract

Typhoid fever is a major health problem with frequent outbreaks in Kelantan, Malaysia. Prevalence of TLR4 gene polymorphisms varies with ethnic groups (0–20%) and predisposean individual to gram-negative infections. The prevalence rate of TLR4 Asp299Gly and Thr399lle polymorphisms in the Malay population or the influence of these on typhoid fever susceptibility is not yet reported.

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Key words

Typhoid fever,TLR4 polymorphisms,Malay ethnicity

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