Tropisetron-Dexamethasone Combination For Carboplatin-Induced Emesis

Sixty-six patients being given polychemotherapy schedules including carboplatin entered an antiemetic protocol with tropisetron and dexamethasone at the dose of 5 mg and 8 mg respectively. A complete response (no episodes of vomiting) and a major response (less than or equal to 2 episodes of vomiting) were observed in 55 and and 7 patients respectively. It is concluded that the tropisetron-dexamethasone combination is highly active in the control of emesis induced by conventional doses of carboplatin in combination.