A-90289 A and B, new inhibitors of bacterial translocase I, produced by Streptomyces sp. SANK 60405
JOURNAL OF ANTIBIOTICS(2011)
摘要
During the course of screening for translocase I inhibitors, the new liposidomycin-related compounds, A-90289 A and B, were isolated from a culture broth of Streptomyces sp. SANK 60405. The structural elucidations were carried out by NMR and high-resolution mass spectral analyses, and they were classified as members of the liponucleoside antibiotics group with a sulfate group at the C-2′ position. A-90289 A and B inhibited bacterial translocase I with IC 50 values of 36.5 ng ml −1 and 33.8 ng ml −1 , respectively.
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关键词
FAB/CID,NMR,nucleoside antibiotics,sulfate,sulfotransferase,translocase I
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