Hepatitis C And Autoimmunity: A Therapeutic Challenge
JOURNAL OF INTERNAL MEDICINE(2012)
Abstract
Bockle BC, Baltaci M, Ratzinger G, Graziadei I, Vogel W, Sepp NT (Innsbruck Medical University, Anichstrasse, Innsbruck, Austria). Hepatitis C and autoimmunity: a therapeutic challenge (Case Report). J Intern Med 2012; 271: 104106.Hepatitis C virus (HCV) infection causes not only acute and chronic liver disease, but also extrahepatic symptoms. To our knowledge, this is the first case report of a patient who developed simultaneously sub-acute cutaneous lupus erythematosus and a small CD20+ B-cell clone because of chronic HCV infection and relapse after standard of care therapy (pegylated interferon plus ribavirin). Treatment with rituximab, a chimeric anti-CD20 monoclonal antibody, was successful.
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Key words
autoimmunity,B-cell clone,hepatitis C,lupus erythematosus,rituximab
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