Phrma Cpcdc Initiative on Predictive Models of Human Pharmacokinetics, Part 3: Comparative Assessement of Prediction Methods of Human Clearance

Barbara J. Ring,Jenny Y. Chien,Kimberly K. Adkison,Hannah M. Jones,Malcolm Rowland,Rhys Do Jones,James W. T. Yates,M. Sherry Ku,Christopher R. Gibson,Handan He,Ragini Vuppugalla,Punit Marathe,Volker Fischer,Sandeep Dutta,Vikash K. Sinha,Thorir Bjornsson,Thierry Lave,Patrick Poulin

JOURNAL OF PHARMACEUTICAL SCIENCES（2011）

引用 189|浏览23

关键词

clearance,pharmacokinetics,disposition,protein binding,in vitro-in vivo correlation (IVIVC),computanional ADME,first time in human,scaling,elimination,allometry

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