Identification and characterization of new inhibitors of fungal homoserine kinase.
CHEMBIOCHEM（2011）
Abstract
The aspartate pathway in fungi is a well-validated antimicrobial target. Deletion of homoserine kinase (THR1) has been proven to lead to a chemical-synthetic lethal phenotype in the presence of several bioactive molecules. We have identified and characterized several Thr1 inhibitors that can be used in combination therapy against fungal infections.
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Key words
antifungal agents,high-throughput screening,homoserine kinase,kinase inhibitors,THR1
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