B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies
NATURE MEDICINE(2011)
摘要
Edgar Engleman and his colleagues show that B cell production of pathogenic IgG antibodies is involved in obesity-induced insulin resistance. They also show that B cell depletion in obese mice ameliorates metabolic disease, and that obese, insulin-resistant humans have a unique profile of IgG autoantibodies. These results suggest a possible new therapeutic target to treat insulin resistance.
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nature medicine, science
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