Changes in hepatobiliary enzymes and its isoenzymes in intrahepatic cholestasis in pregnancy]

Serum alkaline phosphatase (AKP), gamma-glutamyl transpeptidase (gamma-GT), 5'-nucleotidase (5'-NT), leucine aminopeptidase (LAP), AKP gamma-GT isoenzymes, and lipoprotein-X (LP-X) were measured in 97 normal pregnant women and 40 patients with intrahepatic cholestasis of pregnancy (ICP). It was found that in ICP the changing patterns in the four hepatobiliary enzymes were different in different gestational weeks of 3 rd trimester. The changes of gamma-GT and 5'NT were more significant, especially the latter. Six bands were found both in serum AKP and gamma-GT isoenzymes. In ICP the rate of occurrence of AKP1 and AKP2 isoenzymes were elevated. Thus, gamma-GT, 5'-NT, AKP and gamma-GT isoenzymes might be more sensitive parameters for monitoring intrahepatic cholestasis of pregnancy.