Depolarization-induced presynaptic calcium accumulation may occur by an N-type channel that is blocked by flunarizine.

Annals of the New York Academy of SciencesVolume 635, Issue 1 p. 397-399 Depolarization-Induced Presynaptic Calcium Accumulation May Occur by an N-Type Channel That Is Blocked by Flunarizine STANLEY L. COHAN, STANLEY L. COHAN Department of Neurology, 3800 Reservoir Road, N. W., Georgetown University, Washington, D.C. 20007Search for more papers by this authorMEI CHEN, MEI CHEN Department of Neurology, 3800 Reservoir Road, N. W., Georgetown University, Washington, D.C. 20007Search for more papers by this authorDAVID REDMOND, DAVID REDMOND Department of Neurology, 3800 Reservoir Road, N. W., Georgetown University, Washington, D.C. 20007Search for more papers by this authorDAHLIA WILSON, DAHLIA WILSON Department of Neurology, 3800 Reservoir Road, N. W., Georgetown University, Washington, D.C. 20007Search for more papers by this author STANLEY L. COHAN, STANLEY L. COHAN Department of Neurology, 3800 Reservoir Road, N. W., Georgetown University, Washington, D.C. 20007Search for more papers by this authorMEI CHEN, MEI CHEN Department of Neurology, 3800 Reservoir Road, N. W., Georgetown University, Washington, D.C. 20007Search for more papers by this authorDAVID REDMOND, DAVID REDMOND Department of Neurology, 3800 Reservoir Road, N. W., Georgetown University, Washington, D.C. 20007Search for more papers by this authorDAHLIA WILSON, DAHLIA WILSON Department of Neurology, 3800 Reservoir Road, N. W., Georgetown University, Washington, D.C. 20007Search for more papers by this author First published: October 1991 https://doi.org/10.1111/j.1749-6632.1991.tb36508.xCitations: 6AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Holler, M., H. Dierking, D. Dengler, F. Tegtmeyer & T. Peters. 1986. Effect of flunarizine on extracellular ion concentration in the rat brain under hypoxia and ischemia. In Acute Brain Ischemia. N. Battistine, R. Courbier, P. Fiorani, F. Plum & C. Fieschi, Eds.: 229–233. Raven Press. New York . 2 Siesjo, B. K. 1981. Cell damage in the brain: a speculative synthesis. J. Cereb. Blood Flow Metab. 1: 155–185. 3 Van Reempts, J. & M. Borgers. 1985. Ischemic brain injury and cell calcium; morphologic and therapeutic aspects. Ann. Emerg. Med. 14: 736–742. 4 Has, W. K. 1981. Beyond cerebral blood flow, metabolism, and ischemic thresholds: An examination of the role of calcium in the initiation of cerebral infarction. In Cerebral Vascular Disease. J. S. Meyer, H. Lochner, M. Reivich, E. O. Ott & R. Aranibar, Eds. 3: 3–17. Excepta Medica. Amsterdam . 5 Benveniste, H., J. Dreger, A. Schousboe & N. H. Diemer. 1985. Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J. Neurochem. 40: 189–201. 6 Komulainen H. & S. C. Bondy. 1987. The estimation of free calcium within synaptosomes and mitochondria with Fura-2; comparison to quin-2. Neurochem. Int. 10: 55–64. 7 Grynkiewicz, G., M. Poenie & R. Y. Tsien. 1985. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260: 3440–3450. 8 Fox, A. P., M. C. Nowycky & R. W. Tsien. 1987. Kinetic and pharmacologic properties distinguishing three types of calcium currents in chick sensory neurones. J. Physiol. (Lond.) 394: 149–172. 9 Cohan, S. L., D. Von Lubitz, D. Redmond, S. Szathmary & J. A. Waxman. 1989. The effects of flunarizine on survival following prolonged cerebral ischemia in the gerbil. In Cerebral Ischemia and Calcium. A. Hartmann and W. Kuschinsky, Eds.: 483–493. Springer-Verlag. Berlin . 10 Van Reempts, J., M. Haseldoncky, B. Van Deuven, L. Wouters & M. Borgers. 1986. Structural damage of the ischemic brain involvement of calcium and effects of post-ischemic treatment with calcium entry blockers. Drug Dev. Res. 8: 387–395. 11 De Ryck, M. J. Van Reempts, M., Borgers, A. Wauquier & P. A. J. Janssen. 1989. Photochemical stroke model: flunarizine prevents sensormotor deficits after neocorti-cal infarcts in rats. Stroke 20: 1383–1390. Citing Literature Volume635, Issue1Calcium Entry and Action at the Presynaptic Nerve TerminalOctober 1991Pages 397-399 ReferencesRelatedInformation