Strain conformation, primary structure and the propagation of the yeast prion [ PSI + ]

[ PSI+ ] is a well-studied prion from budding yeast. Here the dominant-negative effects of mutation G58D are found to depend on the prion conformation. Moreover, the curing effect of G58D on one particular prion conformation is attributed to an impact on the delivery of infectious particles from the mother to the daughter cells.