Oral ω-3 PUFA supplementation modulates inflammation in adipose tissue depots in morbidly obese women: A randomized trial

•In obesity, low-grade inflammation is present in adipose tissue.•Adipose tissue depots have different inflammatory and metabolic characteristics.•Local macrophages initiate and sustain inflammation with cytokines.•In experimental studies, ω-3 fatty acids act as anti-inflammatory nutrients.•In morbidly obese women, oral supplementation reduced macrophage markers.