Hot spots of integrase genotypic changes leading to HIV-2 resistance to raltegravir.

Charpentier Charlotte,Roquebert Bénédicte,Delelis Olivier,Larrouy Lucile,Matheron Sophie,Tubiana Roland,Karmochkine Marina,Duval Xavier,Chêne Geneviève,Storto Alexandre,Collin Gilles,Bénard Antoine,Damond Florence,Mouscadet Jean-François,Brun-Vézinet Françoise,Descamps Diane, Null Null

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY（2011）

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摘要

We studied seven heavily pretreated HIV-2-infected patients exhibiting a virological failure while receiving a salvage raltegravir-containing regimen. At the time of virological failure, different resistance genetic pathways were observed: T97A-Y143C, Q148K, Q148R, G140S-Q148R, E92Q-Y143R-N155H, and T97A-N155H. Thus, despite a 40% difference in integrase genes between HIV-1 and HIV-2, the genetic pathways leading to raltegravir resistance are similar.

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关键词

genotype,hiv integrase

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