Inhibition of lactic dehydrogenase as a way to increase the anti-proliferative effect of multi-targeted kinase inhibitors.

Luigi Fiume,Marina Vettraino,Marcella Manerba,Giuseppina Di Stefano

Pharmacological Research（2011）

引用 36|浏览7

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摘要

Reduction of ATP levels by oxamic acid potentiates the effect of sorafenib on human hepatocellular carcinoma cells causing an early manifestation of cell death.

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关键词

Aerobic glycolysis,Kinase inhibitors,Hepatocellular carcinoma,Lactic dehydrogenase

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