[Survival analysis on advanced non-small cell lung cancer with a Buckley-James model].

OBJECTIVE:To analyze the risk factors related to survival time of advanced non-small cell lung cancer (NSCLC) and to establish a prediction model on survival time. METHODS:From 2004 - 2006, 184 patients with advanced NSCLC were enrolled in the Affiliated Hospital to the Nantong Medical College. Related risk factors were analyzed, using the Buckley-James model. Both actual and predicted survival time were compared by log-rank test. RESULTS:Through Buckley-James model analysis, data showed that KPS, clinical stage, treatment and pre-treatment hemoglobin were main influencing factors on survival time. Regression equation appeared to be lnMONTH=0.0108 KPS+0.0238 HB+0.4614 IIIb+0.8027 IIIa+0.3869 (radiotherapy+chemotherapy)+0.507 (radiotherapy + operation) + 0.6082 (chemotherapy + operation) - 2.098. There was no statistical difference between the prediction and the actual models of survival time by log-rank test (P=0.575>0.05). CONCLUSION:KPS, clinical stage, treatment and pre-treatment hemoglobin might be associated. Both the prognosis of patients with advanced NSCLC and the prediction model seemed to have practical significances.