Synthesis and antimicrobial activity of new bromine-rich pyrrole derivatives related to monodeoxypyoluteorin.
European Journal of Medicinal Chemistry（2006）
Abstract
The synthesis and antimicrobial activity of new pyrrole derivatives structurally related to monodeoxypyoluteorin are described. The insertion of a keto or methylene spacer between the phenol group and the pyrroloyl moiety of brominated 2-(2′-hydroxybenzoyl)pyrroles leads to a decrease of the antibacterial activity.
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Key words
Antimicrobics,Bromopyrroles,Pyoluteorin analogs
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