Surface-active agents from the group of polyoxyethylated glycerol esters of fatty acids. Part I. Basic thermodynamics values of a structure, and the level of hydrophilic/lipophilic balance (HLB) of the oxyethylenation products of Lard's fractions (Adeps suillus FP VI)]

Polimery w medycynie(2010)

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摘要
Research was conducted into the properties and identity of the oxyethylenation products of triglycerides derived from Lard (Adeps suillus) using original, stereoselective catalyst K-4. Determined of drop-point temperature -Tk (273.15 + t degrees C) allowed for calculation coefficients of volumetric dilatability--alpha (v0), linear dilatability--alpha(l0) as well as structural viscosity of the product (eta) in the state of equilibrium liquefaction. The solubility parameter delta(1/2) and the required numerical value of HLB(R )were calculated for oxyethylated product's fractions. The number of oxyethylated segments -n(TE) was determined by 1HNMR method, it made possible to estimate the weight-average molecular mass Mw, and also structural (m. Griffin) and analitycal (m. 1HNMR) level of hydrophilic/lipophilic balance--HLB. The results obtained in the course of research served as a basis for determine application properties of oxyethylated products of triglycerides fractions, in particular for the purpose of examination them for using as a transdermal passage promotors and micellar solubilizers for lipophilic therapeutic agents belonging to BCS Class II and III.
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关键词
polyoxyethylated glycerol esters,fatty acids,oxyethylenation products,hydrophilic/lipophilic balance,[surface-active
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